We are interested in understanding how biological organisms process information using complex biochemical networks and how such networks can be engineered to program cellular behavior. The focus of our research is the identification of systematic design rules for the de novo construction of biological control circuits with DNA and RNA components. Our approach integrates the design of molecular circuitry in the test tube and in the cell with the investigation of existing biological pathways. Engineered circuits are being applied to problems in disease diagnostics and therapy.
9/17: Our position paper on variant interpretation using massively parallel reporter assays is out in AJHG!
7/17 Gourab's paper is now online at Nature Nano: A spatially localized architecture for fast and modular DNA computing. See also News & Views by Esteves-Torres and Rondelez.
6/17: NSF is funding our work on DNA diagnostics. Nice work Randolph!
6/17: Congratulations, Dr. Chatterjee!!
6/17: Gourab's paper on localized DNA circuits was accepted at Nature Nanotechnology (also on bioRxiv). Congratulations Gourab!
5/17: Sumit and Yue's paper on learning from scRNA-seq data is out on bioRxiv
5/17: Congratulations to Charlie for passing his quals! Awesome research proposal!
5/17: Congratulations to Sifang, Sunny and Sherry for getting their papers accepted at DNA23!
5/17: Yeast 5'UTR library paper by Anna. Ben, Alex and our friends Josh Cuperus, Stan Fields and Nebosja Jojic is is now on bioRxiv
5/17 Georg visited ETH in Zurich and Max Planck Institute for Molecular Cell Biology and Genetics in Dresden
4/17: Our lab was awarded an R01 from NHGRI (with Jay Shendure)!
4/17: Lab alumnus Richard Muscat runs Zurich Marathon in 3:17
3/17: Charlie wins a Translational Research Training Program graduate fellowship. Congratulations!
3/17: Georg gives a talk on localized DNA circuits and DNA diagnostics at the 1st European Congress on Cell-Free Synthetic Biology
2/17: Georg gives talks on SPLiT-seq and splicing at the Friedrich Miescher Institute and the ETH DBSSE in Basel
1/17: Gourab presents his work on DNA circuits at the RNA Nanotechnology Gordon Research Conference